LRRC37A

Across TCGA patient cohorts, LRRC37A mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC37A-associated genes across cancer lineages are Notch1, p38-MAPK_pT180_Y182, and 4E-BP1_pT37_T46. Each is linked with LRRC37A in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC37A-to-partner and partner-to-LRRC37A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by LRRC37A-low versus LRRC37A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC37A→partner) and Y-score (partner→LRRC37A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.230	+2.820	.002	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.553	-3.156	.025	.020	3	1
UCEC	4E-BP1_pT37_T46 →	-0.588	-2.986	.004	.035	3	1
UCEC	EGFR_pY1068 →	-0.301	-3.169	.029	.020	2	1
UCEC	PCNA →	+0.349	+3.169	.003	.020	1	1
UCEC	Rictor_pT1135 →	-0.136	-3.169	.015	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by LRRC37A expression — UCEC

Explore this box plot interactively →