LRRC37A

Across TCGA cell cohorts, LRRC37A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,431 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC37A-associated GO terms across cancer lineages are Constitutive heterochromatin formation, Negative regulation of gene expression, epigenetic, and DNA biosynthetic process. Each is linked with LRRC37A in more than 14 cancer types. Because this analysis shows association rather than direction, both LRRC37A-to-partner and partner-to-LRRC37A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Constitutive heterochromatin formation grouped by LRRC37A-low versus LRRC37A-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC37A→partner) and Y-score (partner→LRRC37A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Constitutive heterochromatin formation →	+0.088	+0.480	<.001	<.001	3	15
STOMACH	Negative regulation of gene expression, epigenetic →	+0.077	+0.557	.005	.006	3	14
UPPER_AERODIGESTIVE_TRACT	DNA biosynthetic process →	+0.069	+0.522	<.001	<.001	3	14
STOMACH	Epigenetic regulation of gene expression →	+0.076	+0.483	<.001	.001	3	13
LUNG_NSCLC_LUSC	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.119	+0.584	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.127	+0.349	.001	.004	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,431 associations by consensus.

Constitutive heterochromatin formation by LRRC37A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →