LRRC37A

Across TCGA cell cohorts, LRRC37A mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LRRC37A-associated genes across cancer lineages are NKX2-6, TLE7, and IL36RN. Each is linked with LRRC37A in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC37A-to-partner and partner-to-LRRC37A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by LRRC37A-low versus LRRC37A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC37A→partner) and Y-score (partner→LRRC37A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
BLOOD_Lymphoma	IL36RN →	+0.052	+4.321	<.001	.002	3	1
BLOOD_Lymphoma	TMEM174 →	+0.211	+3.736	.003	.009	3	1
BLOOD_Lymphoma	OR2T27 →	+0.041	+3.927	.001	.004	3	1
LUNG_NSCLC_LUAD	OR6M1 →	+0.058	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

NKX2-6 by LRRC37A expression — BLOOD_Leukemia

Explore this box plot interactively →