LRRC36

Across TCGA pan-cancer cohorts, LRRC36 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LRRC36 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LRRC36 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC36 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

HNSC, KIRP, and LIHC are the cancer types where LRRC36 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.154	0.715	<.001	31	view →
KIRP	OS	Median	All	0.135	0.703	.002	12	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
LUSC	OS	Median	II,III,IV	0.181	0.742	.011	12	view →
BLCA	DFS	Median	II,III,IV	1.000	0.334	.040	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LRRC36–HNSC (DFS)

Open the HNSC breakdown →