LRRC36

Across TCGA cell cohorts, LRRC36 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC36-associated genes across cancer lineages are RTP3, LIM2, and IFNA10. Each is linked with LRRC36 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC36-to-partner and partner-to-LRRC36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTP3 grouped by LRRC36-low versus LRRC36-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC36→partner) and Y-score (partner→LRRC36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RTP3 →	+0.177	+3.295	.007	.009	3	2
URINARY_TRACT	LIM2 →	+0.046	+5.087	<.001	.004	3	1
URINARY_TRACT	IFNA10 →	+0.030	+5.087	<.001	.004	3	1
URINARY_TRACT	CCL16 →	+0.013	+5.087	<.001	.004	3	1
BREAST	OR4C6 →	+0.508	+4.199	<.001	.007	3	1
LUNG_SCLC	CRP →	+0.086	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

RTP3 by LRRC36 expression — LARGE_INTESTINE

Explore this box plot interactively →