LRRC34

Across TCGA patient cohorts, LRRC34 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC34-associated genes across cancer lineages are JNK_pT183_Y185, Bap1-c-4, and Cyclin-B1. Each is linked with LRRC34 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC34-to-partner and partner-to-LRRC34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by LRRC34-low versus LRRC34-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC34→partner) and Y-score (partner→LRRC34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.194	-2.321	.001	.005	3	2
UCEC	Bap1-c-4 →	+0.218	+3.604	.006	.001	3	2
UCEC	Cyclin-B1 →	+0.618	+2.584	.002	.010	3	2
UCEC	14-3-3_beta →	-0.078	-2.432	.034	.018	3	1
UCEC	eEF2 →	+0.358	+2.584	.006	.010	3	1
UCEC	EGFR_pY1068 →	-0.219	-2.222	.017	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

JNK_pT183_Y185 by LRRC34 expression — UCEC

Explore this box plot interactively →