LRRC34

Across TCGA pan-cancer cohorts, LRRC34 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LRRC34’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LRRC34 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRRC34 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

COAD, THCA, and KIRC are the cancer types where LRRC34 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC34 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.693	<.001	10	view →
THCA	All	All	−0.370	<.001	8	view →
KIRC	All	All	−0.289	.001	8	view →
UCEC	All	All	−1.185	<.001	6	view →
BRCA	All	III,IV	−0.661	<.001	6	view →
LUAD	Female	All	−0.504	.001	6	view →
LIHC	All	All	+0.108	<.001	6	view →
KICH	Female	II,III,IV	−0.904	<.001	5	view →
LUSC	Male	III,IV	−1.417	.012	4	view →
CHOL	All	All	+0.846	.001	3	view →
HNSC	Male	II,III,IV	+0.281	.018	3	view →
ESCA	Female	All	+0.796	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LRRC34–COAD

Open the COAD breakdown →