LRRC34

Across TCGA cell cohorts, LRRC34 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,256 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible LRRC34-associated GO terms across cancer lineages are Negative regulation of microtubule depolymerization, Regulation of metaphase plate congression, and Adenosine metabolic process. Each is linked with LRRC34 in more than 5 cancer types. Because this analysis shows association rather than direction, both LRRC34-to-partner and partner-to-LRRC34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of microtubule depolymerization grouped by LRRC34-low versus LRRC34-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC34→partner) and Y-score (partner→LRRC34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of microtubule depolymerization →	+0.052	+1.205	<.001	<.001	3	6
KIDNEY	Regulation of metaphase plate congression →	+0.076	+1.034	.002	.004	3	6
BONE	Adenosine metabolic process →	-0.245	-1.233	.001	.006	3	6
LUNG_NSCLC_LUSC	Morphogenesis of an epithelial fold →	-1.480	-1.984	<.001	<.001	3	6
BLOOD_Leukemia	Protein depalmitoylation →	+0.113	+1.294	<.001	<.001	3	5
BONE	Astral microtubule organization →	+0.120	+1.255	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,256 associations by consensus.

Negative regulation of microtubule depolymerization by LRRC34 expression — BLOOD_Leukemia

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