LRRC32

Across TCGA cell cohorts, LRRC32 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC32-associated genes across cancer lineages are MPC1L, OR2V2, and SCN10A. Each is linked with LRRC32 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC32-to-partner and partner-to-LRRC32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPC1L grouped by LRRC32-low versus LRRC32-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC32→partner) and Y-score (partner→LRRC32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MPC1L →	+0.083	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR2V2 →	+0.032	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	SCN10A →	+0.004	+4.662	<.001	.005	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1
LARGE_INTESTINE	VHLL →	+0.138	+3.607	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MPC1L by LRRC32 expression — URINARY_TRACT

Explore this box plot interactively →