LRRC31

Across TCGA patient cohorts, LRRC31 mutation is significantly associated with the RNA expression of many other genes, with 2,049 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC31-associated genes across cancer lineages are ATF4P2, TRAJ12, and LPCAT2BP. Each is linked with LRRC31 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC31-to-partner and partner-to-LRRC31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATF4P2 grouped by LRRC31-low versus LRRC31-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC31→partner) and Y-score (partner→LRRC31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	ATF4P2 →	+0.036	+4.409	.005	.006	3	3
UCEC	TRAJ12 →	+0.458	+1.774	.002	.007	3	3
CESC	LPCAT2BP →	+0.026	+4.969	<.001	.004	3	2
GBM	USP9YP2 →	+0.072	+6.189	<.001	.001	3	2
UCEC	ATP2A1-AS1 →	+0.836	+2.202	<.001	.001	3	2
SKCM	MIR4516 →	+0.209	+2.010	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,049 associations by consensus.

ATF4P2 by LRRC31 expression — CESC

Explore this box plot interactively →