LRRC3

Across TCGA cell cohorts, LRRC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,012 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible LRRC3-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Nucleoside triphosphate metabolic process. Each is linked with LRRC3 in more than 10 cancer types. Because this analysis shows association rather than direction, both LRRC3-to-partner and partner-to-LRRC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by LRRC3-low versus LRRC3-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC3→partner) and Y-score (partner→LRRC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of myoblast fusion →	+0.098	+1.001	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.120	+0.829	<.001	.003	3	11
UPPER_AERODIGESTIVE_TRACT	Nucleoside triphosphate metabolic process →	+0.064	+0.842	<.001	<.001	3	10
OVARY	Purine nucleoside triphosphate metabolic process →	+0.066	+0.959	.007	.002	3	10
OVARY	Ribonucleoside triphosphate biosynthetic process →	+0.072	+1.071	.001	<.001	3	10
OVARY	Purine ribonucleoside triphosphate metabolic process →	+0.069	+0.919	.005	.004	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,012 associations by consensus.

Negative regulation of myoblast fusion by LRRC3 expression — BREAST

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