LRRC3

Across TCGA pan-cancer cohorts, LRRC3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LRRC3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LRRC3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRRC3 is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

HNSC, LUAD, and KIRP are the cancer types where LRRC3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.308	<.001	12	view →
LUAD	Male	All	−0.826	<.001	10	view →
KIRP	All	III,IV	+1.364	<.001	7	view →
BRCA	All	All	−0.452	<.001	6	view →
THCA	Male	III,IV	−1.034	<.001	5	view →
CHOL	All	All	−1.862	<.001	3	view →
STAD	Female	All	−1.551	.016	3	view →
LIHC	Male	II,III,IV	−1.169	.002	3	view →
UCEC	All	All	−0.881	.001	2	view →
PRAD	All	All	+0.185	.021	2	view →
BLCA	Male	IV	−1.562	.008	1	view →
KICH	All	All	−0.439	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LRRC3–HNSC

Open the HNSC breakdown →