LRRC3

Across TCGA cell cohorts, LRRC3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC3-associated genes across cancer lineages are KRTAP4-4, ZNF804B, and POTED. Each is linked with LRRC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC3-to-partner and partner-to-LRRC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-4 grouped by LRRC3-low versus LRRC3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC3→partner) and Y-score (partner→LRRC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KRTAP4-4 →	+0.046	+5.196	<.001	.005	3	1
LARGE_INTESTINE	ZNF804B →	+0.015	+5.415	.001	.004	3	1
BLOOD_Leukemia	POTED →	+0.372	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP4-11 →	+0.029	+5.539	<.001	.003	3	1
LUNG_NSCLC_LUAD	PNLIP →	+0.005	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	IL31 →	+0.051	+4.212	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

KRTAP4-4 by LRRC3 expression — OVARY

Explore this box plot interactively →