LRRC23

Across TCGA cell cohorts, LRRC23 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC23-associated genes across cancer lineages are C1orf87, APOL5, and TGM6. Each is linked with LRRC23 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC23-to-partner and partner-to-LRRC23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf87 grouped by LRRC23-low versus LRRC23-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC23→partner) and Y-score (partner→LRRC23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	C1orf87 →	+0.021	+4.867	.008	.009	3	1
BLOOD_Leukemia	APOL5 →	+0.012	+4.060	.002	.003	3	1
BLOOD_Leukemia	TGM6 →	+0.018	+4.984	<.001	.002	3	1
BLOOD_Leukemia	TACR3 →	+0.028	+4.060	<.001	.003	3	1
BLOOD_Leukemia	CCT8L2 →	+0.011	+3.874	<.001	.005	3	1
BLOOD_Leukemia	OR10R2 →	+1.212	+3.551	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

C1orf87 by LRRC23 expression — BLOOD_Lymphoma

Explore this box plot interactively →