LRRC23

Across TCGA pan-cancer cohorts, LRRC23 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated LRRC23 data layer compared with 1 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher LRRC23 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated LRRC23 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BRCA show a favorable association.

SKCM, COAD, and BRCA are the cancer types where LRRC23 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	II,III,IV	0.309	0.159	<.001	60	view →
COAD	DFS	Tertile	All	0.704	0.850	<.001	53	view →
BRCA	OS	Median	III,IV	0.941	0.866	.004	37	view →
KIRP	OS	Quartile	All	0.868	0.607	.005	26	view →
UVM	OS	Quartile	All	0.910	0.493	.013	26	view →
ESCA	DFS	Median	All	0.918	0.495	.012	19	view →
KICH	DFS	Quartile	All	0.689	1.000	.012	18	view →
UCS	DFS	Median	II,III,IV	0.534	0.192	.007	16	view →
LIHC	OS	Median	All	0.387	0.685	.003	15	view →
READ	DFS	Quartile	II,III,IV	0.930	0.380	.023	13	view →
DLBC	DFS	Quartile	II,III,IV	0.396	1.000	.012	12	view →
OV	DFS	Tertile	III,IV	0.594	0.474	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

LRRC23–SKCM (DFS)

Open the SKCM breakdown →