LRRC15

Across TCGA pan-cancer cohorts, LRRC15 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LRRC15 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher LRRC15 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated LRRC15 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

UVM, BLCA, and UCEC are the cancer types where LRRC15 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.037	0.858	<.001	36	view →
BLCA	DFS	Median	All	0.174	0.625	.023	12	view →
UCEC	DFS	Median	II,III,IV	0.875	0.306	.035	8	view →
LUSC	DFS	Median	III,IV	0.079	0.751	.024	6	view →
SCLC	DFS	Median	All	1.000	0.389	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LRRC15–UVM (OS)

Open the UVM breakdown →