LRRC15

Across TCGA pan-cancer cohorts, LRRC15 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LRRC15’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LRRC15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRRC15 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, LUAD, and BLCA are the cancer types where LRRC15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+2.768	<.001	12	view →
LUAD	Male	III,IV	+3.389	<.001	9	view →
BLCA	All	III,IV	+1.872	<.001	9	view →
COAD	Female	All	+1.541	<.001	8	view →
LUSC	All	II,III,IV	+2.646	<.001	7	view →
BRCA	All	III,IV	+3.803	<.001	6	view →
STAD	Male	II,III,IV	+1.532	<.001	6	view →
THCA	Female	All	−1.312	<.001	6	view →
READ	All	II,III,IV	+1.832	.009	4	view →
PAAD	All	All	+1.875	.027	2	view →
KICH	All	All	+0.362	.016	2	view →
CHOL	All	All	+0.830	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LRRC15–HNSC

Open the HNSC breakdown →