LRRC15

Across TCGA cell cohorts, LRRC15 mutation is significantly associated with the RNA expression of many other genes, with 135 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC15-associated genes across cancer lineages are OOSP4A, PRR32, and SPATA31A7. Each is linked with LRRC15 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC15-to-partner and partner-to-LRRC15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OOSP4A grouped by LRRC15-low versus LRRC15-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC15→partner) and Y-score (partner→LRRC15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OOSP4A →	+0.042	+4.285	<.001	.007	3	2
KIDNEY	PRR32 →	+0.013	+5.000	<.001	.005	3	1
KIDNEY	SPATA31A7 →	+0.043	+5.000	<.001	.005	3	1
BLOOD_Myeloma	SLCO1C1 →	+0.054	+4.700	<.001	<.001	3	1
BLOOD_Myeloma	CPSF4L →	+0.032	+3.754	<.001	.002	3	1
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 135 associations by consensus.

OOSP4A by LRRC15 expression — STOMACH

Explore this box plot interactively →