Across TCGA cell cohorts, LRRC14B mutation is significantly associated with the mutation status of many other genes, with 3,821 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC14B-associated genes across cancer lineages are KCNH8, ADAMTS12, and ITPR3. Each is linked with LRRC14B in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRC14B-to-partner and partner-to-LRRC14B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC14B→partner) and Y-score (partner→LRRC14B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KCNH8 →	+3.954	+4.906	.001	.001	1	4
UPPER_AERODIGESTIVE_TRACT	ADAMTS12 →	+3.217	+4.442	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	ITPR3 →	+4.954	+4.392	.008	.008	1	4
BLOOD_Lymphoma	HECTD4 →	+2.710	+4.203	.008	.008	1	4
CNS	TAP2 →	+5.862	+5.199	<.001	<.001	1	3
CNS	MROH7 →	+5.277	+4.459	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,821 associations by consensus.

Exploration

LRRC14B survival (RNA) · tumor vs normal (RNA) · all LRRC14B data types