LRRC14

Across TCGA patient cohorts, LRRC14 mutation is significantly associated with the RNA expression of many other genes, with 1,553 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC14-associated genes across cancer lineages are C2orf69P4, LRRC57, and RPS27L. Each is linked with LRRC14 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC14-to-partner and partner-to-LRRC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C2orf69P4 grouped by LRRC14-low versus LRRC14-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC14→partner) and Y-score (partner→LRRC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C2orf69P4 →	+0.084	+7.741	<.001	.009	3	2
UCEC	LRRC57 →	+0.539	+3.491	<.001	.002	3	2
UCEC	RPS27L →	+0.633	+3.343	<.001	.005	3	2
UCEC	CMC1 →	+0.406	+3.606	.001	.001	3	2
UCEC	IGHD3-16 →	+1.235	+1.943	<.001	.003	3	2
UCEC	VDAC1 →	+0.506	+3.595	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,553 associations by consensus.

C2orf69P4 by LRRC14 expression — COAD

Explore this box plot interactively →