LRRC14

Across TCGA cell cohorts, LRRC14 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,335 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LRRC14-associated GO terms across cancer lineages are Positive regulation of intracellular estrogen receptor signaling pathway, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with LRRC14 in more than 15 cancer types. Because this analysis shows association rather than direction, both LRRC14-to-partner and partner-to-LRRC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular estrogen receptor signaling pathway grouped by LRRC14-low versus LRRC14-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC14→partner) and Y-score (partner→LRRC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.149	+0.949	<.001	<.001	3	16
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.154	+1.019	<.001	<.001	3	15
URINARY_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.131	+1.044	<.001	<.001	3	15
SOFT_TISSUE	Negative regulation of calcium ion export across plasma membrane →	+0.074	+1.053	.001	<.001	3	14
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.120	+0.974	<.001	<.001	3	14
BONE	DNA topological change →	+0.127	+0.921	.002	.007	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,335 associations by consensus.

Positive regulation of intracellular estrogen receptor signaling pathway by LRRC14 expression — BONE

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