LRR1

Across TCGA cell cohorts, LRR1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRR1-associated genes across cancer lineages are MSGN1, TAFA1, and C14orf180. Each is linked with LRR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRR1-to-partner and partner-to-LRR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by LRR1-low versus LRR1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRR1→partner) and Y-score (partner→LRR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1
LARGE_INTESTINE	C14orf180 →	+0.176	+3.155	<.001	.008	3	1
LARGE_INTESTINE	CD300H →	+0.036	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	VAX1 →	+0.740	+3.519	<.001	.007	2	1
LARGE_INTESTINE	SLN →	+0.158	+3.443	.003	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MSGN1 by LRR1 expression — LARGE_INTESTINE

Explore this box plot interactively →