LRPPRC

Across TCGA patient cohorts, LRPPRC mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRPPRC-associated genes across cancer lineages are 14-3-3_beta, MEK1, and PDCD4. Each is linked with LRPPRC in more than 2 cancer types. Because this analysis shows association rather than direction, both LRPPRC-to-partner and partner-to-LRPPRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by LRPPRC-low versus LRPPRC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRPPRC→partner) and Y-score (partner→LRPPRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.104	-2.295	.001	.005	3	2
UCEC	MEK1 →	+0.399	+1.938	<.001	.001	3	2
UCEC	PDCD4 →	-0.560	-2.415	<.001	.002	3	2
COAD	ASNS →	+0.470	+3.008	.022	.019	2	3
UCEC	A-Raf_pS299 →	-0.149	-2.502	<.001	.001	3	1
UCEC	ERK2 →	+0.136	+2.000	.032	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

14-3-3_beta by LRPPRC expression — UCEC

Explore this box plot interactively →