LRPPRC

Across TCGA pan-cancer cohorts, LRPPRC RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of LRPPRC’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where LRPPRC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRPPRC is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

STAD, LUAD, and LIHC are the cancer types where LRPPRC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRPPRC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Male	II,III,IV	+1.105	<.001	9	view →
LUAD	Male	All	+0.917	<.001	9	view →
LIHC	Male	II,III,IV	+0.910	<.001	9	view →
HNSC	All	III,IV	+0.558	<.001	9	view →
LUSC	Male	II,III,IV	+1.255	<.001	8	view →
BLCA	All	All	+0.530	<.001	8	view →
THCA	All	All	−0.330	<.001	8	view →
COAD	Male	II,III,IV	+0.517	<.001	7	view →
BRCA	All	II,III,IV	+0.338	<.001	6	view →
KIRC	All	All	−0.256	.003	6	view →
CHOL	All	All	+1.493	<.001	5	view →
KICH	Female	All	−0.749	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

LRPPRC–STAD

Open the STAD breakdown →