LRPPRC

Across TCGA cell cohorts, LRPPRC mutation is significantly associated with the RNA expression of many other genes, with 256 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRPPRC-associated genes across cancer lineages are PRAMEF4, MAD2L1, and RNLS. Each is linked with LRPPRC in more than 1 cancer types. Because this analysis shows association rather than direction, both LRPPRC-to-partner and partner-to-LRPPRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF4 grouped by LRPPRC-low versus LRPPRC-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRPPRC→partner) and Y-score (partner→LRPPRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRAMEF4 →	+0.005	+4.285	<.001	.007	3	2
LARGE_INTESTINE	MAD2L1 →	+0.575	+3.064	.009	.009	3	2
LARGE_INTESTINE	RNLS →	-1.518	-3.416	<.001	.002	3	2
LARGE_INTESTINE	MT-ND3 →	-0.664	-3.416	.003	.002	3	2
SOFT_TISSUE	IL17F →	+0.054	+4.930	<.001	.008	3	1
URINARY_TRACT	LY6G6F →	+0.040	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 256 associations by consensus.

PRAMEF4 by LRPPRC expression — STOMACH

Explore this box plot interactively →