LRP6

Across TCGA pan-cancer cohorts, LRP6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LRP6 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher LRP6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated LRP6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where LRP6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	1.000	0.615	.013	8	view →
CCRCC	OS	Median	II,III,IV	0.297	1.000	.022	3	view →
LSCC	DFS	Median	III,IV	1.000	0.774	.048	2	view →
PDAC	DFS	Median	II,III,IV	0.725	0.223	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LRP6–LUAD (OS)

Open the LUAD breakdown →