LRP6

Across TCGA pan-cancer cohorts, LRP6 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of LRP6’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LRP6 RNA is repressed in tumor relative to normal tissue. In most cancer types LRP6 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUAD are the cancer types where LRP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.232	<.001	9	view →
KICH	Female	All	−1.309	<.001	6	view →
LUAD	All	III,IV	−0.605	.005	6	view →
BRCA	Female	II,III,IV	−0.505	<.001	6	view →
KIRC	All	All	−0.452	<.001	6	view →
STAD	All	II,III,IV	+0.711	.003	5	view →
LIHC	All	All	+0.433	.004	3	view →
UCEC	All	All	−0.479	.030	2	view →
COAD	Male	All	+0.292	.036	2	view →
KIRP	Male	All	−0.526	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

LRP6–THCA

Open the THCA breakdown →