LRP6

Across TCGA patient cohorts, LRP6 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP6-associated genes across cancer lineages are JNK2, Ku80, and 4E-BP1. Each is linked with LRP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRP6-to-partner and partner-to-LRP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by LRP6-low versus LRP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP6→partner) and Y-score (partner→LRP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.234	+2.348	<.001	.002	3	2
SKCM	Ku80 →	+0.357	+2.584	.005	.011	3	2
SKCM	4E-BP1 →	+0.356	+3.000	.011	.035	3	2
UCEC	14-3-3_beta →	-0.073	-1.558	.016	.032	3	2
UCEC	eEF2 →	+0.277	+1.906	.010	.014	3	2
UCEC	A-Raf_pS299 →	-0.106	-1.321	.003	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

JNK2 by LRP6 expression — UCEC

Explore this box plot interactively →