LRP6

Across TCGA cell cohorts, LRP6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,456 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRP6-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Heterochromatin organization, and Heterochromatin formation. Each is linked with LRP6 in more than 16 cancer types. Because this analysis shows association rather than direction, both LRP6-to-partner and partner-to-LRP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by LRP6-low versus LRP6-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP6→partner) and Y-score (partner→LRP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of chromosome condensation →	+0.155	+1.147	<.001	<.001	3	17
BLOOD_Lymphoma	Heterochromatin organization →	+0.070	+1.588	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Heterochromatin formation →	+0.076	+1.036	.001	<.001	3	16
BONE	Epigenetic regulation of gene expression →	+0.085	+1.613	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Negative regulation of gene expression, epigenetic →	+0.076	+1.098	.001	<.001	3	16
STOMACH	Regulation of nucleotide-excision repair →	+0.139	+1.394	.002	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,456 associations by consensus.

Negative regulation of chromosome condensation by LRP6 expression — LIVER

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