LRP6

Across TCGA cell cohorts, LRP6 mutation is significantly associated with the RNA expression of many other genes, with 324 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRP6-associated genes across cancer lineages are AVP, ZNF716, and RESP18. Each is linked with LRP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRP6-to-partner and partner-to-LRP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by LRP6-low versus LRP6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP6→partner) and Y-score (partner→LRP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.028	+2.310	<.001	.005	3	2
URINARY_TRACT	ZNF716 →	+0.299	+4.584	.004	.002	3	1
BREAST	RESP18 →	+0.072	+5.169	<.001	.005	3	1
SKIN	ODF4 →	+0.031	+4.977	<.001	.007	3	1
SKIN	OR14A16 →	+0.019	+5.415	<.001	.004	3	1
SKIN	CLEC4C →	+0.067	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 324 associations by consensus.

AVP by LRP6 expression — LARGE_INTESTINE

Explore this box plot interactively →