LRP5L

Across TCGA patient cohorts, LRP5L mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP5L-associated genes across cancer lineages are Ku80, 4E-BP1, and 14-3-3_beta. Each is linked with LRP5L in more than 1 cancer types. Because this analysis shows association rather than direction, both LRP5L-to-partner and partner-to-LRP5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by LRP5L-low versus LRP5L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP5L→partner) and Y-score (partner→LRP5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.348	+2.335	<.001	.003	3	2
UCEC	4E-BP1 →	+0.272	+2.351	.014	.018	3	2
UCEC	14-3-3_beta →	-0.093	-2.295	.025	.033	3	1
UCEC	FOXO3a →	-0.093	-2.670	.027	.006	3	1
UCEC	GATA3 →	-0.166	-3.149	.033	.019	3	1
UCEC	ACC1 →	+0.532	+3.335	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Ku80 by LRP5L expression — UCEC

Explore this box plot interactively →