LRP5L

Across TCGA pan-cancer cohorts, LRP5L RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of LRP5L’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LRP5L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRP5L is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

COAD, LIHC, and HNSC are the cancer types where LRP5L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRP5L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.945	<.001	10	view →
LIHC	All	II,III,IV	+0.473	<.001	8	view →
HNSC	Male	All	+0.443	<.001	8	view →
THCA	Male	All	+1.034	<.001	7	view →
UCEC	All	All	+0.577	.004	6	view →
READ	Female	All	+1.329	<.001	5	view →
STAD	All	All	+0.546	.001	5	view →
CHOL	All	All	+1.187	.001	4	view →
LUAD	Female	All	+0.387	.026	1	view →
BRCA	Female	II,III,IV	−0.192	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

LRP5L–COAD

Open the COAD breakdown →