LRP5L

Across TCGA cell cohorts, LRP5L mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRP5L-associated genes across cancer lineages are MC2R, PRAMEF7, and ETNPPL. Each is linked with LRP5L in more than 1 cancer types. Because this analysis shows association rather than direction, both LRP5L-to-partner and partner-to-LRP5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MC2R grouped by LRP5L-low versus LRP5L-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP5L→partner) and Y-score (partner→LRP5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MC2R →	+0.032	+4.807	<.001	.003	3	1
OVARY	PRAMEF7 →	+0.033	+4.228	.002	.006	3	1
LARGE_INTESTINE	ETNPPL →	+0.228	+3.758	.001	.004	3	1
LARGE_INTESTINE	TMCO5A →	+0.020	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	ACSM6 →	+0.023	+3.658	<.001	.005	3	1
LARGE_INTESTINE	FAM162B →	+0.113	+3.510	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MC2R by LRP5L expression — OVARY

Explore this box plot interactively →