LRP5

Across TCGA patient cohorts, LRP5 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP5-associated genes across cancer lineages are PDCD4, PKC-b-II_pS660, and ATM. Each is linked with LRP5 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRP5-to-partner and partner-to-LRP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by LRP5-low versus LRP5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP5→partner) and Y-score (partner→LRP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PDCD4 →	-0.382	-1.691	.017	.043	3	3
COAD	PKC-b-II_pS660 →	-0.434	-3.700	.001	.001	3	3
COAD	ATM →	-0.671	-3.700	<.001	.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.302	+3.476	<.001	.002	3	3
UCEC	MEK1 →	+0.332	+2.137	.001	<.001	3	3
UCEC	STAT3_pY705 →	-0.241	-1.662	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

PDCD4 by LRP5 expression — COAD

Explore this box plot interactively →