LRP5

Across TCGA pan-cancer cohorts, LRP5 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated LRP5 data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LRP5 RNA is associated with better overall survival. In most high-consensus cancer types, elevated LRP5 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

KIRC, SCLC, and CESC are the cancer types where LRP5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.768	0.501	<.001	153	view →
SCLC	DFS	Median	All	0.717	0.521	.003	68	view →
CESC	DFS	Median	All	0.655	0.828	<.001	66	view →
COAD	DFS	Tertile	II,III,IV	0.660	0.860	.001	26	view →
THYM	DFS	Median	All	0.936	0.802	.008	17	view →
GBM	DFS	Median	All	0.373	0.200	.010	15	view →
ACC	OS	Tertile	IV	0.778	0.264	.024	14	view →
HNSC	OS	Tertile	All	0.280	0.524	.018	14	view →
THCA	DFS	Quartile	All	0.925	0.552	.003	14	view →
DLBC	DFS	Median	All	0.614	0.922	.006	13	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →
BLCA	OS	Median	All	0.461	0.685	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

LRP5–KIRC (OS)

Open the KIRC breakdown →