LRP5

Across TCGA cell cohorts, LRP5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,879 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible LRP5-associated GO terms across cancer lineages are Norrin signaling pathway, Extracellular matrix-cell signaling, and Bone marrow development. Each is linked with LRP5 in more than 19 cancer types. Because this analysis shows association rather than direction, both LRP5-to-partner and partner-to-LRP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Norrin signaling pathway grouped by LRP5-low versus LRP5-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP5→partner) and Y-score (partner→LRP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Norrin signaling pathway →	+1.691	+2.690	<.001	<.001	3	20
SOFT_TISSUE	Extracellular matrix-cell signaling →	+1.045	+1.536	<.001	<.001	3	17
BREAST	Bone marrow development →	+0.273	+1.167	<.001	<.001	3	16
BLOOD_Myeloma	Retinal blood vessel morphogenesis →	+1.677	+2.484	<.001	<.001	3	11
URINARY_TRACT	Regulation of amyloid precursor protein biosynthetic process →	+0.120	+1.332	.003	.002	3	11
STOMACH	Cytotoxic T cell degranulation →	+0.222	+1.608	.008	.005	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,879 associations by consensus.

Norrin signaling pathway by LRP5 expression — BLOOD_Lymphoma

Explore this box plot interactively →