LRP5

Across TCGA cell cohorts, LRP5 mutation is significantly associated with the RNA expression of many other genes, with 1,244 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRP5-associated genes across cancer lineages are PRSS38, NEK6, and GRSF1. Each is linked with LRP5 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRP5-to-partner and partner-to-LRP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS38 grouped by LRP5-low versus LRP5-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP5→partner) and Y-score (partner→LRP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PRSS38 →	+0.070	+4.643	<.001	.008	3	3
BLOOD_Leukemia	NEK6 →	-2.525	-3.584	<.001	.001	3	3
BLOOD_Leukemia	GRSF1 →	+0.467	+3.354	.001	.003	3	3
BLOOD_Leukemia	TRMT10B →	+0.483	+3.321	.003	.005	3	3
LARGE_INTESTINE	YEATS4 →	+0.493	+3.131	.007	.008	3	3
LUNG_NSCLC_LUSC	OR2M4 →	+0.220	+4.643	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,244 associations by consensus.

PRSS38 by LRP5 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →