LRP4-AS1

Across TCGA pan-cancer cohorts, LRP4-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of LRP4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LRP4-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRP4-AS1 is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

THCA, KIRP, and KIRC are the cancer types where LRP4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRP4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	+1.520	<.001	9	view →
KIRP	All	All	+0.175	.002	7	view →
KIRC	Male	All	+0.123	<.001	7	view →
LIHC	All	II,III,IV	+0.145	<.001	6	view →
UCEC	All	All	+0.748	<.001	4	view →
BRCA	Female	All	−0.100	<.001	4	view →
COAD	Female	IV	+0.455	.007	3	view →
LUAD	Female	II,III,IV	−0.365	.001	3	view →
STAD	Male	IV	+0.350	.034	2	view →
LUSC	All	All	+0.182	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

LRP4-AS1–THCA

Open the THCA breakdown →