LRP2

Across TCGA pan-cancer cohorts, LRP2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LRP2 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LRP2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LRP2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, GBM, and LUAD are the cancer types where LRP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.973	0.835	.009	19	view →
GBM	DFS	Median	All	0.916	0.630	.007	14	view →
LUAD	DFS	Quartile	All	0.595	1.000	.019	12	view →
OV	DFS	Median	All	0.496	0.819	.044	8	view →
LSCC	OS	Tertile	III,IV	0.980	0.639	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LRP2–CCRCC (DFS)

Open the CCRCC breakdown →