LRP2

Across TCGA patient cohorts, LRP2 mutation is significantly associated with the total protein of many other genes, with 101 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP2-associated genes across cancer lineages are ASNS, PKC-b-II_pS660, and TFRC. Each is linked with LRP2 in more than 5 cancer types. Because this analysis shows association rather than direction, both LRP2-to-partner and partner-to-LRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by LRP2-low versus LRP2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP2→partner) and Y-score (partner→LRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.316	+1.222	<.001	.025	3	6
COAD	PKC-b-II_pS660 →	-0.265	-1.643	.001	.002	3	4
LUAD	TFRC →	+0.400	+2.584	.019	.009	3	4
COAD	Caspase-7-cleavedD198 →	+0.879	+1.395	<.001	<.001	3	4
LUAD	Cyclin-B1 →	+0.500	+2.807	.001	.003	3	4
UCEC	Tuberin →	+0.178	+1.273	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

ASNS by LRP2 expression — COAD

Explore this box plot interactively →