LRP2

Across TCGA cell cohorts, LRP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,911 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible LRP2-associated GO terms across cancer lineages are Regulation of mRNA catabolic process, Negative regulation of mRNA metabolic process, and Regulation of RNA stability. Each is linked with LRP2 in more than 9 cancer types. Because this analysis shows association rather than direction, both LRP2-to-partner and partner-to-LRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA catabolic process grouped by LRP2-low versus LRP2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP2→partner) and Y-score (partner→LRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of mRNA catabolic process →	+0.059	+0.301	<.001	.002	3	10
OVARY	Negative regulation of mRNA metabolic process →	+0.047	+0.764	.002	.003	3	8
LUNG_NSCLC_LUSC	Regulation of RNA stability →	+0.041	+0.236	.004	<.001	3	8
LUNG_NSCLC_LUSC	Regulation of mRNA stability →	+0.060	+0.299	<.001	.002	3	7
LUNG_NSCLC_LUSC	RNA catabolic process →	+0.049	+0.282	<.001	<.001	3	7
PANCREAS	Regulation of mRNA processing →	+0.070	+0.141	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,911 associations by consensus.

Regulation of mRNA catabolic process by LRP2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →