LRP1B

Across TCGA patient cohorts, LRP1B mutation is significantly associated with the RNA expression of many other genes, with 12,616 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP1B-associated genes across cancer lineages are CENPU, NEK2, and HSPB6. Each is linked with LRP1B in more than 7 cancer types. Because this analysis shows association rather than direction, both LRP1B-to-partner and partner-to-LRP1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by LRP1B-low versus LRP1B-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP1B→partner) and Y-score (partner→LRP1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	CENPU →	+0.563	+2.906	<.001	<.001	3	8
STAD	NEK2 →	+0.649	+1.412	<.001	<.001	3	8
STAD	HSPB6 →	-1.494	-1.192	<.001	<.001	3	8
LIHC	RRM2 →	+0.685	+1.438	.005	.005	3	7
STAD	MELK →	+0.657	+1.744	<.001	<.001	3	7
STAD	EXO1 →	+0.545	+1.909	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,616 associations by consensus.

CENPU by LRP1B expression — STAD

Explore this box plot interactively →