LRP1B

Across TCGA pan-cancer cohorts, LRP1B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated LRP1B data layer compared with 13 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher LRP1B RNA is associated with better overall survival. In most high-consensus cancer types, elevated LRP1B expression acts as an unfavorable survival marker, although some lineages such as BRCA and SCLC show a favorable association.

BRCA, SCLC, and UCEC are the cancer types where LRP1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Quartile	All	0.623	0.548	.001	58	view →
SCLC	DFS	Quartile	II,III,IV	0.704	0.299	.002	57	view →
UCEC	DFS	Quartile	All	0.599	0.784	<.001	52	view →
KIRP	OS	Tertile	All	0.892	0.989	.002	46	view →
UVM	DFS	Quartile	All	0.359	0.802	<.001	45	view →
STAD	OS	Median	All	0.343	0.487	.010	37	view →
LGG	DFS	Tertile	All	0.521	0.325	<.001	34	view →
UCS	OS	Tertile	IV	0.156	0.781	.024	24	view →
PAAD	OS	Median	All	0.691	0.536	.005	23	view →
SKCM	OS	Tertile	III,IV	0.528	0.263	.003	19	view →
MESO	DFS	Tertile	II,III,IV	0.637	0.192	.006	18	view →
HNSC	DFS	Quartile	IV	0.444	0.219	.010	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

LRP1B–BRCA (OS)

Open the BRCA breakdown →