LRP1B

Across TCGA cell cohorts, LRP1B mutation is significantly associated with the RNA expression of many other genes, with 1,369 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRP1B-associated genes across cancer lineages are FRMD7, BRPF1, and C17orf58. Each is linked with LRP1B in more than 2 cancer types. Because this analysis shows association rather than direction, both LRP1B-to-partner and partner-to-LRP1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FRMD7 grouped by LRP1B-low versus LRP1B-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP1B→partner) and Y-score (partner→LRP1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FRMD7 →	+0.015	+3.373	.004	.004	3	3
OESOPHAGUS	BRPF1 →	+0.531	+3.000	.008	.007	3	3
BLOOD_Leukemia	C17orf58 →	+0.561	+2.380	.008	.008	3	3
BLOOD_Leukemia	NCBP3 →	+0.534	+2.700	.004	.002	3	3
LUNG_SCLC	SEC61A1 →	+0.549	+2.222	<.001	<.001	3	3
LUNG_NSCLC_LUAD	NRDE2 →	+0.391	+1.053	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,369 associations by consensus.

FRMD7 by LRP1B expression — BLOOD_Myeloma

Explore this box plot interactively →