LRP11

Across TCGA patient cohorts, LRP11 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP11-associated genes across cancer lineages are MEK1, Notch1, and Akt_pS473. Each is linked with LRP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRP11-to-partner and partner-to-LRP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by LRP11-low versus LRP11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP11→partner) and Y-score (partner→LRP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.512	+3.584	.003	.002	3	1
UCEC	Notch1 →	+0.212	+2.183	.001	.033	3	1
UCEC	Akt_pS473 →	-0.866	-3.584	.012	.002	3	1
UCEC	PCNA →	+0.285	+3.169	.006	.018	3	1
UCEC	PDCD4 →	-0.748	-3.160	<.001	.019	3	1
UCEC	PKC-b-II_pS660 →	-0.316	-2.321	.018	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MEK1 by LRP11 expression — UCEC

Explore this box plot interactively →