LRP1-AS

Across TCGA pan-cancer cohorts, LRP1-AS RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated LRP1-AS data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LRP1-AS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRP1-AS expression acts as an unfavorable survival marker, although some lineages such as ACC and READ show a favorable association.

KIRC, ACC, and LGG are the cancer types where LRP1-AS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.535	0.723	<.001	94	view →
ACC	DFS	Median	All	0.635	0.271	<.001	74	view →
LGG	OS	Median	All	0.364	0.527	<.001	45	view →
BLCA	DFS	Median	All	0.161	0.528	.001	44	view →
READ	DFS	Tertile	All	0.866	0.287	.002	33	view →
UVM	DFS	Tertile	III,IV	0.317	0.646	.009	22	view →
THCA	OS	Quartile	II,III,IV	0.608	0.976	.002	22	view →
KICH	OS	Quartile	III,IV	0.235	0.777	.007	20	view →
CHOL	DFS	Median	II,III,IV	0.126	0.622	.005	19	view →
LIHC	DFS	Quartile	All	0.435	0.575	.003	18	view →
STAD	OS	Quartile	II,III,IV	0.608	0.779	.011	15	view →
COAD	DFS	Median	All	0.861	0.720	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

LRP1-AS–KIRC (DFS)

Open the KIRC breakdown →