LRP1-AS

Across TCGA pan-cancer cohorts, LRP1-AS RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of LRP1-AS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LRP1-AS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRP1-AS is over-expressed in tumor.

KIRC, HNSC, and COAD are the cancer types where LRP1-AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRP1-AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+0.119	<.001	12	view →
HNSC	Male	III,IV	+0.151	<.001	8	view →
COAD	Male	All	+0.333	<.001	7	view →
KIRP	All	All	+0.114	<.001	7	view →
STAD	Male	II,III,IV	+0.165	.006	4	view →
THCA	All	IV	+0.132	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

LRP1-AS–KIRC

Open the KIRC breakdown →