Across TCGA patient cohorts, LRIT3 mutation is significantly associated with the RNA expression of many other genes, with 1,384 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRIT3-associated genes across cancer lineages are RNU6-1299P, DSCR4, and KRTAP21-1. Each is linked with LRIT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRIT3-to-partner and partner-to-LRIT3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRIT3→partner) and Y-score (partner→LRIT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-1299P →	+0.316	+4.721	<.001	<.001	3	2
BRCA	DSCR4 →	+0.631	+3.941	<.001	.002	3	2
BRCA	KRTAP21-1 →	+0.089	+4.148	.001	.002	3	2
BRCA	RPL22P8 →	+0.192	+3.788	.008	.006	3	2
UCEC	FAM177A1 →	+0.325	+1.864	.002	.004	3	2
UCEC	SLC35A4 →	+0.313	+2.244	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,384 associations by consensus.

Exploration

LRIT3 survival (RNA) · tumor vs normal (RNA) · all LRIT3 data types