LRIG1

Across TCGA pan-cancer cohorts, LRIG1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated LRIG1 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LRIG1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRIG1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

HNSC, ESCA, and BLCA are the cancer types where LRIG1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.078	0.710	<.001	15	view →
ESCA	OS	Median	III,IV	0.108	0.574	<.001	12	view →
BLCA	OS	Median	II,III,IV	0.933	0.699	.024	11	view →
LIHC	DFS	Median	All	0.077	0.527	.002	9	view →
CESC	OS	Median	All	0.277	0.798	.014	6	view →
PRAD	DFS	Median	All	0.617	0.886	.018	6	view →
SARC	DFS	Median	All	0.081	0.632	<.001	6	view →
UCEC	DFS	Median	All	0.790	0.628	.016	6	view →
STAD	OS	Median	II,III,IV	0.250	0.709	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

LRIG1–HNSC (DFS)

Open the HNSC breakdown →