LRIG1

Across TCGA pan-cancer cohorts, LRIG1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LRIG1 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher LRIG1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LRIG1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, UCEC, and PDAC are the cancer types where LRIG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.815	0.603	.007	32	view →
UCEC	OS	Tertile	All	0.864	1.000	.016	10	view →
PDAC	DFS	Quartile	II,III,IV	0.552	0.894	.011	8	view →
GBM	DFS	Median	All	0.240	0.495	.006	6	view →
LUAD	DFS	Median	All	0.759	0.539	.019	4	view →
HNSC	DFS	Quartile	II,III,IV	0.871	1.000	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LRIG1–LSCC (DFS)

Open the LSCC breakdown →